NFL Week 2 research · Updated Sep 15, 5:00 PM CT

NFL Week 2 predictions, odds and best-bet research

The entire weekly board is published as soon as the schedule is available and refreshed as U.S. sportsbook prices, injuries and conditions change.

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Complete Week 2 slate

16 games on the board

Detroit Lions vs. Buffalo BillsThursday, September 17 · 7:15 PM CT · 6 approved books reporting

Buffalo Bills -4.5 · Total 53.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Buffalo Bills are favored by 4.502

Carolina Panthers vs. Atlanta FalconsSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Carolina Panthers -2.5 · Total 43.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Carolina Panthers are favored by 2.503

New Orleans Saints vs. Baltimore RavensSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Baltimore Ravens -8.5 · Total 46.75. Open the matchup for injuries, weather, exact paired prices and key-number context.

Baltimore Ravens are favored by 8.504

Minnesota Vikings vs. Chicago BearsSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Chicago Bears -5.5 · Total 48.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Chicago Bears are favored by 5.505

Cincinnati Bengals vs. Houston TexansSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Houston Texans -2.5 · Total 46.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Houston Texans are favored by 2.506

Cleveland Browns vs. Tampa Bay BuccaneersSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Tampa Bay Buccaneers -8.5 · Total 41. Open the matchup for injuries, weather, exact paired prices and key-number context.

Tampa Bay Buccaneers are favored by 8.507

Green Bay Packers vs. New York JetsSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Green Bay Packers -3.5 · Total 44.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Green Bay Packers are favored by 3.508

Pittsburgh Steelers vs. New England PatriotsSunday, September 20 · 12:00 PM CT · 6 approved books reporting

New England Patriots -5 · Total 41.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

New England Patriots are favored by 509

Philadelphia Eagles vs. Tennessee TitansSunday, September 20 · 12:00 PM CT · 6 approved books reporting

Philadelphia Eagles -7 · Total 39.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Philadelphia Eagles are favored by 710

Jacksonville Jaguars vs. Denver BroncosSunday, September 20 · 3:05 PM CT · 6 approved books reporting

Denver Broncos -2.5 · Total 45.25. Open the matchup for injuries, weather, exact paired prices and key-number context.

Denver Broncos are favored by 2.511

Las Vegas Raiders vs. Los Angeles ChargersSunday, September 20 · 3:05 PM CT · 6 approved books reporting

Los Angeles Chargers -6.5 · Total 43.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Los Angeles Chargers are favored by 6.512

Seattle Seahawks vs. Arizona CardinalsSunday, September 20 · 3:25 PM CT · 6 approved books reporting

Seattle Seahawks -4.5 · Total 41.25. Open the matchup for injuries, weather, exact paired prices and key-number context.

Seattle Seahawks are favored by 4.513

Washington Commanders vs. Dallas CowboysSunday, September 20 · 3:25 PM CT · 6 approved books reporting

Dallas Cowboys -4 · Total 50.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Dallas Cowboys are favored by 414

Miami Dolphins vs. San Francisco 49ersSunday, September 20 · 3:25 PM CT · 6 approved books reporting

San Francisco 49ers -13.5 · Total 45.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

San Francisco 49ers are favored by 13.515

Indianapolis Colts vs. Kansas City ChiefsSunday, September 20 · 7:20 PM CT · 6 approved books reporting

Kansas City Chiefs -6.5 · Total 47. Open the matchup for injuries, weather, exact paired prices and key-number context.

Kansas City Chiefs are favored by 6.516

New York Giants vs. Los Angeles RamsMonday, September 21 · 7:15 PM CT · 5 approved books reporting

Los Angeles Rams -7 · Total 48.5. Open the matchup for injuries, weather, exact paired prices and key-number context.

Los Angeles Rams are favored by 7